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Another autophagy inhibitor 3-MA also produced rescuing effects but to a smaller extent in erastin-treated cells

Gene expression profiling of multiple sclerosis pathology identifies early patterns of demyelination surrounding chronic active lesions

Besides, ATP-binding Cassette Subfamily C Member 5 (ABCC5), an important membrane transporter, is a universal glutamate conjugate that affects the efflux of endogenous metabolites, toxins, drugs, and intracellular ions (Jansen et al., 2015)

Following an increase in intestinal permeability, enterogenic endotoxins and inflammatory mediators can be transported to the pancreas via systemic circulation and mesenteric lymphatic pathways, ultimately exacerbating acute pancreatic inflammation