foxo4 dri senolytic FOXO4-DRI The FOXO4 peptide in a

The FOXO4 peptide in a DRI conformation (D amino acids in a retro reversed sequence), henceforth named FOXO4 DRI, competes with FOXO4 for p53 binding in a dose dependent manner and doing so with higher affinity. foxo4 dri peptide senolytic mouse study 2023 2024 Molecular modelling of the FOXO4 TP53 interaction to design peptides for the elimination of Molecular modelling of the FOXO4 TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells ScienceDirect FOXO4 DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53 serine 15 phosphorylation Communications Biology

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