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In addition, alcohol exerts some harmful effects through its breakdown (i.e., metabolism) and the resulting toxic compounds, particularly in the liver, where most of the alcohol metabolism occurs (Lieber 1992, 2000)

However, neither myoblast- nor myofiber-specific ARKO impacted voluntary running wheel activity in 12-week-old male mice, even with the modest reductions in absolute and relative hindlimb muscle mass and elevations in WAT depot mass in those muscle-specific ARKO lines [183]

However, it remains unclear how genetics affect the abundance of expression features

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