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246 Additionally, ROS activate SRC kinase through Cys-oxidative modification, initiating JAK/STAT signaling

Relative acrolein levels ( j ), and viability analysis ( k ) in SAT1/SMOX/PAOX triple-knockout or MJP-treated PDLCs and SNU449 cells cultured in dFBS medium, pre-treated with vehicle, or spermidine (10 uM), or spermine (10 uM) for 24 h, followed by treatment of vehicle, or RSL3 (1 uM, j ), or erastin (5 uM, j ), or FIN56 (1 uM, j , k ), or FINO2 (5 uM, j , k ) for 24 h