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Others who may not be able to tolerate dosages of vitamin B12 that are higher than what is found in most multivitamins include people who have been diagnosed with low potassium, Leber's vision loss, or atrophic gastritis, according to WebMD

Use outside of clinical trials or approved indications is illegal in many countries

Most medical and experimental protocols emphasize a conservative, progressive approach, beginning with minimal exposure to assess tolerance and biological response