chac1 glutathione CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers L-2-Hydroxyglutarate sensitizes ferroptosis through ATF3/CHAC1-mediated

L 2 Hydroxyglutarate sensitizes ferroptosis through ATF3 CHAC1 mediated glutathione degradation in hepatocellular carcinoma Cell Death & Disease Glutathione specific gammaglutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis Science Translational Medicine CHAC1 degradation of glutathione enhances cystine starvation induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2 eIF2 ATF4 pathway Oncotarget Identification of Juglone, a 'first in class' inhibitor of the human glutathione degrading enzyme, ChaC1, using yeast based high throughput screens bioRxiv

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