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Although the mechanisms underlying increased GSNO reductase activity in asthma are not clear, recent studies have demonstrated increased GSNO reductase activity in response to formaldehyde (303, 316), which is increased in the airways of asthmatics versus controls (as formate) and is associated with airway hyperreactivity and asthma severity in a concentration-dependent manner (116)

Subsequently, SAH is converted to Hcy by SAH hydrolase (SAHase) (Aksoy et al., 1994

If you are using a high-quality, bioavailable format, this sensitivity is often reduced

474 119127 10.1016/j.abb.2008.03.008 [DOI] [PMC free article] [PubMed] [Google Scholar] Zhu H., Santo A., Li Y