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In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019

Following the final placed session, the platform is removed and the swim-pattern of the mice is tracked for one minute

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Given that hypertension remains a major contributing, yet largely preventable, factor in cardiovascular-associated mortality and development of other chronic diseases, including diabetes, garlic as a preventive measure could be recommended