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Practitioners should note that they only work when combined with a healthy lifestyle that promotes weight loss

Targeted evaluation is most appropriate when elevation is unexplained, persistent, or paired with red-flag features, with functional markers added when deficiency remains plausible despite a high total

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Methotrexate can cause serious, life-threatening side effects: liver toxicity, lung disease, bone marrow suppression, infections, and gastrointestinal toxicity