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Intriguingly, a Western diet high in PUFAs can induce intestinal inflammation in mice lacking one allele of GPX4 in IECs, which implies that dietary PUFAs may be a trigger of GPX4-restricted mucosal inflammation phenocopying aspects of human CD (143)

Our studys superior histology results provide evidence for this

Notably, a recent study identified ACSS2, previously known for acetyl-CoA synthetase, as a bona fide lactyl-CoA synthetase

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