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Imatinib targets the ATP-binding site of the BcrAbl tyrosine kinase and also inhibits the actions of other tyrosine kinases, including platelet-derived growth factor receptor-b, C-kit, and C-ABL [17]

This chemical stimulates the production of melanin, which darkens the skin, and while it can supposedly work without UV exposure, its effects are enhanced when used alongside sun exposure or tanning sun beds

Reccurent disease can be treated with repeated metastectomy.[81-83] Ollila et al points out that prolonged disease-free interval prior to recurrence and complete surgical metastasectomy of the recurrence were the two most important prognostic factors for survival after recurrence