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doi: 10.1002/art.20732

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Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis

However, the precise mechanism by which XAN treats AD through altering microbial-derived metabolite levels remains unclear, though it may relate to reduced TMAO levels

Although the effects of most of these mediators have been examined using nerve injury-induced neuropathic pain or inflammatory pain models, but not CIPN, they were shown to be effective against refractory pain syndromes (Xu et al., 2010