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In summary, although current studies suggest that ferroptosis plays a central regulatory role in the pathological sequence of PVLlinking hypoxiaischemia, inflammatory infiltration, and white-matter necrosisand provides a new mechanistic basis for understanding the pathway from periventricular iron accumulation to oligodendrocyte loss and motor developmental impairment, several essential gaps remain

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erinaceus -derived nutraceutical has been demonstrated to be effective in decreasing intestinal inflammation probably, at least in part, due to its prebiotic activity similar to that of other edible mushrooms (8)

In contrast, regulatory approval in Western countries remains limited: in the United States, glycyrrhizin is primarily recognized as a food sweetener rather than a therapeutic agent, while in Europe, its use is largely confined to traditional medicine and flavoring