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( We found that the GPX4 expression and ferrous iron levels were increased in 5-FU- or AZ628-derived tolerant CRC persister cells, which render persister cells sensitive to GPX4 inhibitors-induced ferroptosis

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Toxicol Appl Pharmacol (2017) 329:11220

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2.1.2 Mechanisms linking decreased NAD + levels to MetS Decreased NAD + levels are associated with obesity, with studies demonstrating reduced NAD + levels in obese individuals

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