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Inhibition of hypoxia-induced autophagy was shown to disrupt pSTAT3 signaling through accumulation of p62, which selectively induces pSTAT3 degradation by the proteasome system and thereby restores cytotoxic T-cell mediated killing of tumor cells (273)

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Typically, IL-4 and IL-13 fulfill immunosuppressive roles through inhibiting neutrophil migration, proliferation and production of pro-inflammatory mediators, and phenotype switching of macrophages from M1 pro-inflammatory to M2 anti-inflammatory [112]

It plays a crucial role in helping reduce oxidative stress by neutralizing free radicals that can damage cells and accelerate aging