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Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment

8 weeks (0.251.0 mg/wk): ~1 vial 12 weeks (gradual to 1.7 mg/wk): ~2 vials 16 weeks (gradual to 2.44.5 mg/wk): ~3 vials Insulin Syringes (U-100, 1 mL) Per week: 1 syringe (once-weekly dosing) 12 weeks: 12 syringes 24 weeks: 24 syringes 48 weeks: 48 syringes Bacteriostatic Water (10 mL bottles) Use 2.0 mL (gradual) or 1.0 mL (advanced) per vial for reconstitution

In pregnant rats administered tirzepatide during organogenesis, fetal growth reductions and fetal abnormalities occurred at clinical exposure in maternal rats based on AUC

The optional addition of MOTS-C addresses the mitochondrial dysfunction that underlies menopausal metabolic slowdown