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Results SIRT2 regulates TGFBR1 ubiquitination and degradation through USP2 In our prior publications, we established that SIRT2 exerts inhibitory effects on the TGF signaling cascade, chiefly through the deacetylation and subsequent inactivation of SMAD2/3 in renal tubular epithelial cells (TECs), which play a pivotal role in the progression of renal fibrosis 11,38