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Protein Misfolding and Cellular Stress in Disease and Aging: Concepts and Protocols

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It consists of four subunits generally containing a Se atom incorporated in the form of selenocysteine (Sec), which is recognized today as the twenty-first amino acid, the first major enzyme identified as an intracellular antioxidant

586,587 Similarly, reactive astrocytes are associated with -amyloid deposits in the brains of various transgenic AD models (most of which are models of hyperamyloidosis), although sometimes reactive remodelling of astrocytes precedes formation of -amyloid plaques