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The FDA-approved Mylotarg (gemtuzumab ozogamicin) utilizes an acid-sensitive hydrazone linker to efficiently release the DNA-damaging agent calicheamicin within lysosomes, achieving precise targeting of leukemia cells

Immune/inflammatory regulators Immune-related transcription factors, including NF-B, interferon regulatory factor 8 (IRF8), and signal transducer and activator of transcription (STATs), play pivotal roles in regulating autophagy during infection and inflammation

Additional information Edited by G Kroemer Rights and permissions About this article Cite this article Troyano, A., Sancho, P., Fernndez, C

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death