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doi: 10.1016/S0010-7824(02)00277-9 22 HuangY-YWuC-HLiuC-HYangS-FWangP-HLinL-Yet al

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Mutagenicity of tocopheryl quinones: evolutionary advantage of selective accumulation of dietary a-tocopherol

Supporting this concept, total glutathione concentration appears to declines with aging, as demonstrated in both rat models of aging and in human aging (particularly after age 45 in humans), possibly due to a reduced ability to synthesize GSH