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Despite the early termination of the trial, it is interesting to note that 13 of 140 patients had a median duration of response of 10.2 months, indicating that these patients benefited from combination therapy and that exploring the mechanisms of this benefit should be the focus of future research

In order to develop new treatments for diabetes with natural product characteristics that meet international standards, further clinical studies and evaluation of natural products, as well as structural and mechanism of action, as well as the relationship between biological outcomes and therapeutic effects, are needed