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Elevated ROS levels, especially in the early stages of cancer, can contribute to carcinogenesis by promoting genomic instability, mitogenic signaling pathways, and the NF-B pathway, among others [26]

Second, the development of new drugs requires additional and more detailed preclinical and clinical studies to determine whether long-term use is biotoxic, whether the drug has adverse effects on other peripheral organs or whether the drug candidate has a real therapeutic effect on the patients

Under hypoxic conditions, autophagy has been shown to promote degradation of such aggregates through the CHIP protein (C terminus of Hsc70-interacting protein), suggesting it can be a key element to selectively reduce mutp53 GOF under hypoxic conditions (Maan and Pati, 2018)

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