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2018;27(2):428-438.e5

In addition to the relevance of POP conjugation cited previously, hyperglycemia and hyperinsulinemia appear to directly inhibit glutathione synthesis (GCL), and the increased production of reactive oxygen species which accompanies diabetes further depletes GSH levels

The increased permeability persisted for 4 to 6 weeks as measured by dynamic contrast-enhanced MRI and by tracking serum levels of a brain-specific factor (Table 1) 119