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These advances have led to rapid succession to the approval of the anti-PD-1 antibodies pembrolizumab and nivolumab (both in 2014), followed by the anti-PD-L1 antibodies atezolizumab (in 2016) and durvalumab (in 2017), as second-line therapies for advanced melanoma and metastatic colorectal cancer (mCRC) [37]

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When this happens, for example, fibers responsible for smiling may grow to the muscles at the corner of the mouth and eyelid thus causing lip movement and eye closure instead of a smile

While mild increases in ROS can be conducive to normal cellular functioning by activating the phosphatidyl inositol 3 kinase (PI3K) and mitogen activated-protein kinase (MAPK)/extracellular-regulated kinase 1/2 (ERK1/2) growth signaling, excessive ROS can lead to cell stress and oxidative damage to important macromolecules, ultimately leading to cell death (81, 82)