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6 The complex mechanisms behind the failure of fungal treatment Antifungal treatment failure is a growing clinical challenge, driven not only by pharmacological limitations but also by intrinsic fungal traits

For example, IF has been shown in overweight and obese human subjects during Ramadan to modulate expression of SIRT1, SIRT3, and antioxidant genes, though results are mixed and often depend on gene expression rather than direct functional assays [38]

Food and Drug Administration (2024) FDA clarifies policies for compounders as national GLP-1 supply begins to stabilize, U.S