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Copper ions are the most abundant metal ions in the nucleus of cells, and after treatment with copper chloride, copper ions can enter the nucleus and bind to DNA, leading to DNA fragmentation (143)

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72 In chronic hepatitis B patients, those achieving functional cure have a higher abundance of butyrate-producing bacteria in their gut, and in vitro experiments confirmed that butyrate can directly inhibit HBsAg production in HBV-infected cells, revealing the potential role of SCFAs in antiviral immunity