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The combination of incretin and glucagon signaling axes in a single scaffold offers researchers a tool to interrogate how coordinated multi-receptor activation influences downstream metabolic signaling networks

Certainty of evidence Paired reviewers with experience in using GRADE assessed the certainty of evidence independently and resolved discrepancies by discussion

Christopherson K, Ghosh A, Mohamed ASR, Jomaa M, Gunn GB, Marai L, Canahuate G, Vock D, Dale T, Kalpathy-Cramer J, Messer J, Garden AS, El Halawani H, Frank SJ, Lewin J, Lai SY, Beadle BM, Morrison WH, Phan J, Skinner H, Gross N, Ferrarotto R, Weber RS, Rosenthal DI , Hutcheson K, Fuller CD

Despite advancements in treatments such as cardiac transplantation and mechanical support, barriers like historical biases and immunosuppression concerns persist