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This effect was likely due to attenuation of spinogenesis promoted by HGF and Dihexa treatments since, without the antagonizing effect of Hinge, each agonist increased mini-AMPA frequencies (Figure 13 A-B and Figure 10) thus forming functional synaptic connections

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Additionally, the immunological profile at the single-cell level needs to be investigated to investigate whether nanomaterials induce immune-transcriptional and translational changes upon hybrid NMs exposure

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