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Other observations of a high Ferric/ferrous ratio (Zhao et al., 2023) and abundance of oxidised glutathione (Paik et al., 2003) at the SN microenvironment also support the hypothesis that -synuclein fibrillation is conducive under oxidising conditions

Because we observed that NAM induced the expression of mitochondrial antioxidant enzymes in osteoblasts, we tested whether NAM treatment relieves ROS-damaged osteoblasts

W.PerkinsM

Despite the establishment of numerous animal IC/BPS models to assist in the selection of clinical treatment regimens, no single or combined treatment regimen has been developed that can consistently alleviate IC/BPS symptoms and ensure long-term treatment efficacy 7