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Due to challenges in medicinal chemistry, one antagonist (VENT-03, targeting cGAS) has been advanced into phase I clinical trials, which aims to evaluate the safety of VENT-03 in healthy volunteers, and subsequent trial plans will target the treatment of autoimmune diseases (118)

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STRUCTURE AND FUNCTION OF GGT GGT, an evolutionarily conserved cell surface glycoprotein, is anchored in the cell membrane via its N-terminus, while the catalytic activity resides within the extracellular protein domain [5]