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In recent years various groups have shown that H2O2 is able to activate the MAPK cascade in plants and thus provide the linkage between an upstream H2O2 signal and downstream gene expression (Desikan et al., 1999

J Biol Chem 275:1325913265 Brandsma D, Kerklaan BM, Diras V, Altintas S, Anders CK, Ballester MA, Gelderblom H, Soetekouw PMMB, Gladdines W, Lonnqvist F et al (2014) Phase 1/2a study of glutathione pegylated liposomal doxorubicin (2b3-101) in patients with brain metastases (BM) from solid tumors or recurrent high grade gliomas (HGG)

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As aforementioned, we observed accelerated roGFP2 re-oxidation in the WT, but not in dsbA , when adding monothiols to the cells and the opposite effect for GSSG, compensating the lack of DsbA, raising the question whether DsbB is somehow regulated by glutathione