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doi: 10.1016/j.imlet.2019.02.002

2,97 Studies and clinical practice of treatment of pernicious anaemia with regular high-dose injections has confirmed the safety of B12 at high dosages, and therefore neither the Institute of Medicine (IOM) in the USA nor the European Food Safety Agency (EFSA) have set an upper limit

The use of oral sprays allows for B12 to be delivered directly into the mouth, to permeate the highly vascular tissue of the mucous membrane lining

In the early 1920s, Minot and Murphy demonstrated that they were able to cure PA by whole liver extracts, which were subsequently used for treatment as oral liver extract