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Nutrient supplements and dietary patterns rich in nootropic compounds for NDDs Nutrient supplementation or diets rich in nootropic compounds such as PUFAs, essential amino acids, dietary fibers, polyphenols, and other phytochemicals, hold significant potential for therapeutic intervention of NDDs and mediating brain health outcomes [29, 30]

Concurrently, therapy-induced NF-B activation upregulates APOBEC cytidine deaminases, which catalyze cytidine-to-uracil mutations in single-stranded DNA to fuel genomic instability [47, 48]

Table 8) was performed on DNA isolated from the tumour/blood pair from patient II.2 (Family 2, Fig

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