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New York, NY: Springer New York, pp

Ultimately, tumors exploit this lactateNAD + crosstalk to suppress immune surveillance and establish a protumorigenic, immunosuppressive niche (Fig

This limits the widespread application of ferroptosis-targeting therapies in clinical practice

This conversion directly supports mitochondrial bioenergetics, leading to higher adenosine triphosphate (ATP) levels in hepatocytes (liver cells) and preventing the mitochondrial dysfunction that often accompanies severe toxic burden