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Identification of novel risk and prognostic biomarkers may enable an individualized treatment pathway for patients with DPN from a potentially disease-modifying perspective, and provide onward opportunities for novel treatments that would be efficacious in early stages of DPN, and alter the natural course of the disease

Within this concept, a redox hub can be viewed as an interconnected core of reactions and components able to mediate cross talk between essential bioener- getic processes and signaling pathways

Further, shuffling generally conserves the relative order, such that, for example, CDRl will not be found in the position of CDR2

Tetramethylammonium hydroxide pentahydrate (TMAH) was from Alfa Aesar (Kandel, Germany)