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Support Care Cancer (2006) 14:113440.10.1007/s00520-006-0072-3 19 TurtleMJCullenPPrys-RobertsCCoatesDMonkCRFaroquiMH

Although GHRH-R couples with the G s protein, the addition of MK-0677 to rat primary cultured pituitary cells increased intracellular Ca 2+ levels, suggesting the existence of a second G protein-coupled receptor (GPCR) that couples with the G q protein, thereby promoting GH secretion through a pathway distinct from that of GHRH-R (Patchett et al., 1995)

These filaments have an unusual knobby structure, leading to the name beaded filaments. Beaded filament proteins have only been found in lens fiber cells, suggesting that they have a specialized role in these cells