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368 AD is actually a brain-specific form of diabetes that exhibit increased A accumulation, tau hyperphosphorylation and impaired glucose transportation, energy metabolism, hippocampus and inflammatory pathways

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Indeed, in addition to NKCC1, many K + Cl cotransporter variants have been found at the mRNA levels in mammalian islets including KCC1, three and four splice variants of KCC2 and KCC3, respectively, and KCC4 (Davies et al., 2004

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