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These drugs induce apoptosis inhibition by forming a complex with the intracellular immunophilin FKBP12 thus inhibiting the phosphorylation of the mTOR targets, S6K1 and 4E-BP1, as a result, the activation of cyclin-dependent kinases (CDK) is prevented, specifically, the expression of cyclin D1 is found to be decreased meanwhile p27 increases and consequently, cells arrested at G1/S phase die either by autophagy or apoptosis (197, 198)

The current study aims to elucidate the potential benefits of SIT in mitigating PTX-provoked testicular damage in rats by mediating oxidative stress, ER stress, inflammation, and apoptosis pathways

Mangosteen Known as the queen of fruits, mangosteen contains xanthones antioxidants that protect the liver and lungs

DHA Docosahexaenoic Acid