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10.1016/j.fct.2022.113481 264 YiY.WanS.WangS.KhanA.GuoJ.ZhengX.et al (2021)

Therefore, across various preclinical models and early-stage clinical trials, type I IFN-based therapies (including recombinant IFN- and IFN gene agonists) have been shown to enhance tumor immunogenicity and synergistic effects with ICIs, establishing type I IFN responses as favorable prognostic biomarkers for ICI efficacy [282]