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Shionone alleviates NLRP3 inflammasome mediated pyroptosis in interstitial cystitis injury

Sig Transduct Target Ther 6 , 386 (2021)

Generally, Asian ginseng seems to improve cognitive performance more than American ginseng, though the American form does still have cognitive enhancement potential.22 Korean red ginseng appears to improve concentration, scanning ability, and memory recall and is thought to stabilize the nervous system and decrease neuroinflammation.23 Ginseng also seems to be particularly potent when paired with ginkgo biloba, another nootropic botanical.24 However, a strict meta-analysis from 2010 could only identify five trials that met its stringent requirements for data reliability.102 Among those trials, there was a lack of convincing evidence to show a cognitive enhancing effect of Panax ginseng in healthy participants and no high-quality evidence about its efficacy in patients with dementia. Huperzine A Huperzia serrata (toothed clubmoss) produces a potent compound known as huperzine A

Furthermore, natural products, such as polyphenols, terpenoids, and alkaloids, are likely converted by gut bacteria into bioactive metabolites that can activate the Nrf2/ARE pathway, enhancing the host's antioxidant capacity and contributing to the management of oxidative stress-related diseases