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Brain Lesions, Cerebral and Cerebellar Cortex, Hypothalamus/Thalamus, and Hippocampus Without therapy, the consistently downhill course of ligation of the bile duct at its entry into the duodenum in rats led to multiple organ lesions, widespread thrombosis, disturbed ECG and blood pressure, portal and caval hypertension, aortal hypotension, and in particular, intracranial (superior sagittal sinus) hypertension

This is analogous to how 5-Amino-1MQ works in metabolic research-rather than adding a new signal, it removes a brake on an existing one (NNMT inhibition preserves NAD+

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