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A peak serum concentration of 0.22 g/mL was observed 1 h after oral administration at a dose of 1.0 g/kg in a mouse model, while a peak concentration of 2.25 g/mL was recorded 0.25 h after intraperitoneal administration at the same dose (Pan et al., 1999)

Future studies should incorporate mechanism-relevant biological markers, including serum BDNF to index neurotrophic signaling, inflammatory markers such as CRP and IL-6, measures of HPA-axis activity such as the cortisol awakening response, and neuroimaging markers (e.g., fMRI-based assessments of hippocampal connectivity), to more precisely characterize treatment response and patient stratification