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Interestingly, in this study aimed at assessing the mechanistic role of IGF-1R signaling in the regulation of organ-specific metastasis of platinum-taxol-resistant A2780 EOC cells in orthotopic xenograft mouse models, IGF-1R silencing abrogated organ-specific metastasis of EOC cells augmented by acquired chemoresistance, and enhanced lung homing of the late-stage chemoresistant cells

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In particular, although GS-mediated gene amplification in rCHO cells was mentioned in numerous reports 11,16,17 , it is not clear that GS-mediated gene amplification really occurs in a single round of MSX selection

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