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They include brain atrophy, seizures, severe anemia, pancytopenia, damage to the myelin sheath, and residual post-treatment problems in cognitive and psychomotor development

The 5-Amino-1MQ half life directly informs this strategy

We have found, by simulation, that if we reduce the amino acid input into the system by 15%, the concentration of GSH and the synthesis rate of GSH are proportionally diminished, but there is little effect on the DNA methylation reaction, while reactions in the folate cycle are reduced by 29%

While the nervous system does undergo regulatory processes, its oversimplifying to suggest patients simply need to wait for downregulation to experience relief