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For example, benzene oxide, a reactive species and the first oxidation product of benzene (Figure 1), has been recently shown to be somewhat stable in blood (half-life of 8 min).97 Moreover, benzene oxide adducts with proteins have been measured in rat and mouse bone marrow following administration of benzene.68 The relative importance of benzene oxide to other metabolites is not known at this time

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Current Pharmaceutical Design , 2020 Expected Duration of Effects This explains why some users experience a lagging benefit after finishing their cyclesuch as a tendon continuing to improve or gut symptoms stabilizing well after the last dose