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Long-term, high-dose aspirin use has been associated with decreased VitC levels, which can lead to gastric mucosal thinning, gastritis, peptic ulcer disease, nausea, anorexia, and malnutrition (199, 201)

aeruginosa receiving NAC (2,400 mg/day, 4 weeks) showed improved serum antioxidants, reduced oxidative stress, and better FEV 1 % than controls (109)

The significance of this observation lies in the fact that VEGFR-2 activation is one of the primary pathways that regulate endothelial cell proliferation and the growth of new blood vessels

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