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The researchers theorized that glutathione depletion may play at least a partial causative role in reduced immune response in people with HIV, and that increasing systemic glutathione could improve immune system function in this group

Consistent with this, Li et al

To elucidate the role of METs in ferroptosis of hepatocytes during ischemia-reperfusion injury, they utilized a co-culture model of macrophages exposed to hypoxia/reoxygenation along with hepatocytes