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Interestingly, co-supplementation of these mice with -TOH and coenzyme Q 10 was more effective in inhibiting atherosclerosis than supplementation with either -TOH or coenzyme Q 10 alone (24)

Therapeutic strategies are also limited by metabolic redundancy and individual variability

GLP-1R GLP-1R is a class B1 GPCR that has emerged as a crucial therapeutic target for type 2 diabetes and obesity treatment 133,134

In humans, it must then survive 4 months and hundreds of miles of hazardous travel, subjected to oxidant and osmotic stresses, with very limited equipment with which to maintain itself