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Compounds such as semaglutide and retatrutide are frequently used in metabolic research systems to investigate how different peptide receptor agonists interact with overlapping or complementary endocrine signaling networks

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Electrostatic interaction with the negatively charged phospholipid headgroups and cationic displacement (Ca ++ and Mg ++ ) lead to disturbances in the stability of the membrane and an increase in its permeability, leakage of cell content, and cell death [34,35,36]

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