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SKU: 86730409879
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The RNAscope 2.5 HD Reagent Kit-BROWN (Advanced Cell Diagnostics, #322300) was used according to the manufacturers instructions

HRD1 interacts with the Neh4 and Neh5 domains of NRF2 and causes NRF2 ubiquitination and subsequent degradation through a KEAP1-independent mechanism, just like GSK-3 [227, 228]